EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A TERTIARY CARE CENTRE STUDY OF MALIGNANT SINONASAL MASSES

Nidhi Anand*, Nuzhat Husain, Pradyumn Singh, Namrata P.Awasthi, Anurag Gupta, Saumya Shukla, Subrat Chandra, Ashish Singhal and Akash Agrawal

ABSTRACT

Background: The accurate diagnosis of sinonasal tract tumors is challenging as there is considerable overlapping between clinical features, radiology, histologic and immuno-phenotypic findings. Immunohistochemistry (IHC) aids in reaching a diagnosis. The objectives of the current study were to analyse the clinico-pathological, histomorphological and IHC characteristics of malignant sinonasal masses. Materials and Methods: This is a retrospective case series that included 268 cases of nasal mass. The clinico-pathological findings, histomorphology and IHC profile of all the malignant masses (n=25) were analysed. Results: The study included 268 non-neoplastic cases that were sinonasal polyps, fungal and granulomatous masses, angiofibroma, inverted papilloma etc. and 25 cases of malignant sinonasal mass. Based on the comprehensive histomorphological and IHC profile, 68% (17/25) cases were epithelial malignancies, 12 %(3/25) mesenchymal tumours, 16%(4/25) hematolymphoid malignancies and 4%(1/25) case was of malignant melanoma. The M: F ratio was 1.2:1.The maximum no. of cases 24% (6/25) were between the ages of 51-60 years with mean age of 45.84 years. The major complaint of the cases were nasal obstruction, intermittent epistaxis, rhinorrhoea, hyposmia, eye related symptoms, swelling over face and headache. Conclusion: Malignant sinonasal mass comprises histogenetically diverse entities with overlapping morphologic features. To reach the correct diagnosis histology with IHC must be combined with the imaging findings, and clinical findings, as there are significant differences in therapy and overall outcome.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database