EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

DEVELOPMENT AND EVALUATION OF TOPICAL ANTI-INFLAMMATORY GEL FORMULATIONS CONTAINING PTEROCARPUS MARSUPIUM STANDARDIZED BARK EXTRACT AND CRATAEVA NURVALA STANDARDIZED BARK EXTRACT

Kamini Kashyap*

ABSTRACT

On an individual capacity, both Pterocarpus marsupium and Crataeva nurvala have shown notable anti-inflammatory behavior in animal models. P. marsupium and C. nurvala's synergistic combined in vitro anti-inflammatory activity was recently published, opening up new research avenues. As a result of this, we agreed to develop a topical gel solution that could be used to manage a variety of skin conditions. The aim of this study was to create two topical gel formulations (F1 and F2) with Carbopol 934, propylparaben, methylparaben, triethanolamine, and propylene glycol 400 as active ingredients. Visual consistency, viscosity, transparency, density, pH, removal test, non-volatile matter, irritation test, solubility, swelling index, homogeneity, extrudability, washability, spreadability, thermal stability, centrifugation test, freeze-thaw cycle, and accelerated stability were all used to assess the items. Both plant extracts (P. marsupium and C. nurvala) with strong anti-inflammatory properties were effectively integrated into carbopol-based topical gel formulations, according to the findings. As a consequence, it was determined that the formulation may be a very useful topical or transdermal remedy for inflammatory diseases. More preclinical, clinical, and long-term stability research is required, however.

Keywords: Pterocarpus marsupium, Crataeva nurvala, Anti-inflammatory, Evaluation, Formulations, Topical Gel.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia