DEVELOPMENT AND EVALUATION OF TOPICAL ANTI-INFLAMMATORY GEL FORMULATIONS CONTAINING PTEROCARPUS MARSUPIUM STANDARDIZED BARK EXTRACT AND CRATAEVA NURVALA STANDARDIZED BARK EXTRACT

Kamini Kashyap*

ABSTRACT

On an individual capacity, both Pterocarpus marsupium and Crataeva nurvala have shown notable anti-inflammatory behavior in animal models. P. marsupium and C. nurvala's synergistic combined in vitro anti-inflammatory activity was recently published, opening up new research avenues. As a result of this, we agreed to develop a topical gel solution that could be used to manage a variety of skin conditions. The aim of this study was to create two topical gel formulations (F1 and F2) with Carbopol 934, propylparaben, methylparaben, triethanolamine, and propylene glycol 400 as active ingredients. Visual consistency, viscosity, transparency, density, pH, removal test, non-volatile matter, irritation test, solubility, swelling index, homogeneity, extrudability, washability, spreadability, thermal stability, centrifugation test, freeze-thaw cycle, and accelerated stability were all used to assess the items. Both plant extracts (P. marsupium and C. nurvala) with strong anti-inflammatory properties were effectively integrated into carbopol-based topical gel formulations, according to the findings. As a consequence, it was determined that the formulation may be a very useful topical or transdermal remedy for inflammatory diseases. More preclinical, clinical, and long-term stability research is required, however.

Keywords: Pterocarpus marsupium, Crataeva nurvala, Anti-inflammatory, Evaluation, Formulations, Topical Gel.