EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

COMPARATIVE QSAR STUDY ON ALKYL AND ALKOXY SUBSTITUTED 1, 4 DIHYDROQUINOXALINE-2, 3-DIONES AND 5-(N-OXYAZA)-7-SUBSTITUTED-1, 4-DIHYDROQUINOXALINE-2, 3-DIONES AS GLYCINE/NMDA SITE ANTAGONISTS

Dr. Neelam Khan* and Dr. Manish Sharma

ABSTRACT

In this article demonstrated for glycine site, the inhibition potency was found to be well correlated linearly with lipophilicity  and Hammett constant  parameters of substituent. The models were internally (Q2) and externally (Q2ext) validated and all the statistical parameters met with like leave-one-out cross-validation, an external test set and Y-randomization test. Applicability domain was verified by the standardization approach. Similarly it was also found that any substitution other than CH3 and Cl at R6 will prove to be unfruitful for receptor inhibition. It suggests that there exists a linear relationship with positive slope between  /m and enzyme inhibition, i.e., increasing the value of  and  will increase the potency of the compounds. The coefficient of  is 1.11, which is well between the optimum range of 0.4-1.4. A positive coefficient for  indicates that lipophilic substituents are favorable for inhibiting the receptor. Simultaneously, the substituents should be electron withdrawing also, which is indicated by the positive sign of  coefficient.

Keywords: QSAR, Glycine, NMDA.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia