( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Ishan I. Panchal*, Dr. Dhrubo Jyoti Sen and Dr. Samir K. Shah


Diabetes mellitus (DM) is a major degenerative disease associated with a group of disorders of carbohydrate metabolism results from body's failure to produce insulin in type 1 and insulin resistance in type 2 diabetes mellitus through altered secretion, decreased insulin activity known as hyperglycaemia. There is direct relationship between hyperglycemia and long-term complications such as retinopathy, nephropathy and neuropathy like micro and macrovascular concerns. Existing oral treatment options for T2DM include metformin, sulfonylurea, thiazolidinedione derivatives, glycosidase inhibitors and the recently Dipeptidyl peptidase IV inhibitors which have been introduced successfully. There remains avital need to improve new antidiabetic agents with higher efficacy and lower toxicity for the long term treatment of T2DM.Search for new innocent anti-diabetic agents is still a challenge for medicinal chemists. The detailed study of literature reviewand study we have decided to design and synthesis of novel antidiabetic agents. In order to reduce the space volume of this kind of molecule, we have designed and synthesized a series of cyclohexane, p-Nitro benzoic acid, p-Cl benzoic acid, Cinnamic acid derivatives of sulphonylureas and guanidine.All the synthesize compounds were characterized by melting points, TLC. IR spectroscopy,1H-NMR and 13C-NMR.The synthesized compounds will proposed for biological evaluation by most relevant animal models like alloxan induced diabetic animal model for in-vivo studies.

Keywords: Diabetes mellitus, sulphonylureas, DPP-IV inhibitors, IR, NMR, Mass.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on


    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )