HOW OXIDATIVE STRESS LEADS TO COPD PROGRESSION AND IT’S BASED THERAPIES

Sachindra Kumar*, Preet Verma, Amit Kishor Srivastava, Rohit Mohan and Amresh Gupta

ABSTRACT

Chronic obstructive pulmonary disease is a group of lung disease which generally causes limitation in airflow and make difficulty in breath, it is a progressive and irreversible lung disease and oxidative stress play critical role in COPD progression because overproduction of oxidant either endogenous or exogenous is generate the oxidative stress these oxidative Stress will be damage majorly protein-lipid and DNA, directly and indirectly, damage lungs tissue also and produce inflammation as well as activate the redox-sensitive transcription factor and lead to COPD progression. this study we suggest treating the COPD with the help of antioxidant or we can enhancing endogenous antioxidant most medical studies conduct they have using glutathione generating antioxidant such as carbocysteine, N- acetylcysteine and erdosteine which inhibits the progression of COPD but in this study, we are suggest more antioxidant such as NADPH oxidase inhibitor, a mitochondria-targeted antioxidant superoxide dismutase mimetic.

Keywords: COPD, Oxidative Stress, Antioxidant, Inflammation, Nrf2 activator.