A REVIEW ON: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CETIRIZINE AS AN ANTIHISTAMINIC DRUG
Pritam S. Jain and *Shubham Chandrashekhar Patil
ABSTRACT
In this article, we describe the methodology for the development and validation of cetirizine which is an antihistaminic drug, and a description of the structure, Biochemistry, and pharmacology, the layout, the rate of its absorption, distribution, and identification of the antihistaminic drug. Cetirizine is also a member of the class of piperazines, that is, piperazine, in which the hydrogen attached to the nitrogen is replaced by a (4-chlorophenyl) (phenyl)methyl 2-(carboxymethoxy)ethyl group, respectively. It has an significant role as an anti-allergic agent, an H1-receptor antagonist, environmental degradation, and a xenobiotic. It is a monocarboxylic acid, a member of the piperazines, as well as a member of the monochlorobenzenes, and in the air. Cetirizine Hydrochloride is a synthetic (man-phenylmethyl-piperazinyl derivatives, antihistaminic Cetirizine, a metabolite of hydroxyzine, more explicit for fringe histamine H1-receptor antagonist. It is used to treat the symptoms of seasonal and perennial allergic rhinitis and chronic urticaria (hives).
Keywords: Antihistaminic drugs, validation, absorption, distribution, piperazine, cetirizine Hydrochloride.
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