FACILE SYNTHESIS AND BROAD SPECTRUM PHARMACOLOGY OF NOVEL HETEROCYCLES: DERIVATIVES OF PYRAZOLO PYRIMIDINE WITH BENZOTHIAZOLES AND HYDRAZINO BENZOTHIAZOLES
Pravin R. Jagtap1, Avinash V. Pawde, Sambhaji P. Vartale*
A series of novel bis (substituted benzothiazolo [2,3-b] 4H-imino-pyrimido) [4,3-e] pyrazolo [1,5-a] ,[6,5-d]-4H-oxo-pyrimidines (6a-6f) and 3,9-diamino-6N-phenyl-bis (R) pyrazolo [3,4-c] pyrazolo [1,5-a]-4H-oxo-pyrimidino [4,5-d] pyrazolines (7a-7e) were synthesized via facile condensation of pyrazolo pyrimidine (5) with different benzothiazoles and hydrazino benzothiazoles. The pyrazolo pyrimidine (5) was prepared via reaction between, simple condensation product of phenyl hydrazine (1) and bis(methylthio) methylene malanonitrile (2) that is 3-amino-4-cyano-5-(methylthio)-1-phenyl-1H-pyrazole (3) and ethyl-2-cyano-3,3-bis(methylthio) acrylate (4).These fused heterocycles were examined for their plausible antimycobacterium (against mycobacterium smegmatis), antityphoid (against S. typhi) and antioxidant activity which were found to be more potent and biologically significant heterocycles with least cytotoxicity.
Keywords: Antimycobacterium activity , Antityphoid activity, Antioxidant activity, Benzothiaz
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