AN OVERVIEW OF REMDESIVIR EFFECT AGAINST NOVEL CORONA VIRUS

Rushikesh B. Shinde*, Gaurav D. Borse and Yash S. Shinde

ABSTRACT

Recently the largest war in front of the world is to fight against the Novel coronavirus. Which cause by severe acute respiratory syndrome (SARs CoV-2). It’s big challenge in front of researchers and developing company to prepare drug and vaccine in very short duration of time. In that situation use of other convenient and therapeutic drug is another option useful against covid-19 in 2016 after some clinical trials it is concluded that remdesivir is fully effective against corona virus. After several clinical trials and cell culture study it is establish that remdesivir is an antiviral drug therapeutic effect against covid-19. This virus replication take place by using genetic material with the help of enzyme called as RNA dependent RNA polymerase (RdRp). So Remdesivir is a prodrug of an adenosine -C nucleoside analogue. When remdesivir is enter into body, respiratory epithelial cell in human it gets metabolize by phosphorylation and convert into nucleoside triphosphate as an active form. This active form acts on RdRp and inhibit replication of virus. But knowledge about potency and efficacy of remdesivir therapy to treat Covid -19 and has been limited. Recently WHO said that remdesivir does not show therapeutic effect against Covid-19 and no effect on mortality rate. So, use of remdesivir is restricted in all over India. The basic purpose behind the study of an overview of remdesivir in covid-19 is to understand remdesivir and its pharmacological against viral infection.

Keywords: SARs-CoV-2, remdesivir, drug interaction to body, pharmacokinetic, adverse effect.