DIFFERENT PROMINENT CHOICES OF FIXED DRUG COMBINATION THERAPY FOR THE MANAGEMENT OF HYPERTENSION AND OTHER CARDIOVASCULAR DISEASE WITH SEVERAL THERAPEUTIC OUTCOMES

Sagar Ajabe*, Pratiksha Joshi, Yogita Agrawal and Nitesh Janbandhu

ABSTRACT

Hypertension is a major preventable danger factor for atherosclerosis and ischemic heart disease. Acquiring the objective blood pressure level by monotherapy can be challenging currently, especially for the patients who are suffering from other diseases meanwhile. It is exhibited that a majority of hypertensive patients need two or more antihypertensive drugs to lower their blood pressure effectively. Subsequently, fixed-dose which can be defined as that several active agents were combined in single pharmaceutical formulations appears to be a novel and underlying power in overcoming the cardiovascular disease. In Clinical practices proved that fixed-dose combinations had many advantages comparing with single drug and separate agents in terms of effects, convenience, compliance, and costs to a certain extent. From the patient’s perspective, the fixed-dose combination therapy will be increasingly used in blood pressure control in the future. In this review, we analyze the most latest information available regarding the treatment of hypertension with combination treatment.

Keywords: Antihypertensive drugs, fixed dose combination therapy, cardiovascular disease, Hypertension, Monotherapy, and Therapeutic Outcomes.