REVIEW ON FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET AZELNIDIPINE BY USING SOLVENT EVAPORATION

Gadage Ashwini Nadkumar*, Dr. Vijaya Barge and Vaishali Anna Shingade

ABSTRACT

The aim of this study was to develop a month dissolving tablets(MDT) by solid dispersion using hydrophilic substances to enhance its dissolution (%) and oral bioavailability in rats. MDT-SD formulations were prepared with various co-polymers using a solvent evaporation method. The physical properties of MDT-SD formulations were confirmed using field emission scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and attenuated total reflectance Fourier transform infrared (ATR-FT-IR) spectroscopy. The toxicity and oral bioavailability of MDT-SD formulations were evaluated. Formulations were evaluated for Weight variation, hardness, and thickness, friability, wetting time uniformity of dispersion, drug content, disintegration time and in vitro dissolution studies. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. Optimized formulation showed good release profile with maximum drug being released at all-time intervals.

Keywords: Mouth Dissolving tablets, Solvent evaporation, solubility, polymer.