EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF GROUP 4 METALLOCENE POLY (AMINE ESTERS) FROM 6-AMINOPENICILLANIC ACID AND THEIR AIBLITY TO INHIBIT SOLID TUMOR CANCER CELL GROWTH

Charles E. Carraher, Jr.*, Michael R. Roner, Dhruivin Patel, Alisa Moric-Johnson, Lindsey Miller, Paul Slawek, Francesca Mosca, Jessica Frank and Loretta Chen

ABSTRACT

Poly (amine esters) were synthesized employing interfacial polycondensation of the salt of 6-amiopenicillanic acid and group 4 metallocene dichlorides in decent yield and high chain lengths. Infrared spectroscopy shows bands characteristic of the expected N-M and C(C=O)-O-M linkages with the backbone consisting of largely asymmetrical units present in a non-bridged structure. MALDI MS shows ion fragments to 7 and 8 units long with good isotopic abundance agreements. The polymers inhibit the growth of all of the human cancer cell lines including two breast and two pancreatic cancers.

Keywords: Group 4 metallocene poly (amine esters), 6-aminopenicillanic acid, pancreatic cancer, breast cancer, MALDI MS, interfacial polycondensation.

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