SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF GROUP 4 METALLOCENE POLY (AMINE ESTERS) FROM 6-AMINOPENICILLANIC ACID AND THEIR AIBLITY TO INHIBIT SOLID TUMOR CANCER CELL GROWTH

Charles E. Carraher, Jr.*, Michael R. Roner, Dhruivin Patel, Alisa Moric-Johnson, Lindsey Miller, Paul Slawek, Francesca Mosca, Jessica Frank and Loretta Chen

ABSTRACT

Poly (amine esters) were synthesized employing interfacial polycondensation of the salt of 6-amiopenicillanic acid and group 4 metallocene dichlorides in decent yield and high chain lengths. Infrared spectroscopy shows bands characteristic of the expected N-M and C(C=O)-O-M linkages with the backbone consisting of largely asymmetrical units present in a non-bridged structure. MALDI MS shows ion fragments to 7 and 8 units long with good isotopic abundance agreements. The polymers inhibit the growth of all of the human cancer cell lines including two breast and two pancreatic cancers.

Keywords: Group 4 metallocene poly (amine esters), 6-aminopenicillanic acid, pancreatic cancer, breast cancer, MALDI MS, interfacial polycondensation.