EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

EFFECT OF CRINUM JAGUS EXTRACTS ON LIPIDS PARAMETERS AND NON ALCOHOLIC HEPATIC STEATOSIS IN MACAPOS 1 INDUCED DIABETES RATS

Clémence Mvongo*, Adamou Mfopa, René Kamgang and Jean-Louis Essame Oyono

ABSTRACT

Diabetes is associated with metabolic disorder, including alterations of lipid profile and fat tissue accumulation, which causes among other pathologies, non-alcoholic fatty liver disease. The aim of this work was to investigate the effect of Crinum jagus extracts on lipids parameters and non-alcoholic hepatic steatosis in MACAPOS 1 induced diabetes rats. To induce diabetes, wistar rats (6-8 weeks old) were fed with high sugar diet (HSD) associated, one month after the beginning of the HSD, with dexamethasone (DXM) injection (25 μg/kg once after 2 days during 3 weeks). During 50 days, diabetic rats once daily orally received Metformine (38 mg/kg b.w.), hydroethanolic (75, 150 mg/kg b.w.) and aqueous (150 mg/kg b.w.) extracts. After the induction, diabetic rats presented, overweight, insulin resistance, polydipsia, dyslipidemia associated with increased visceral fat, liver damage lipid peroxydation associated with decrease in antioxidant defense. Crinum jagus extracts remarkably improved the insulin sensitivity of peripheral tissues, reduced body weight gain, seric total cholesterol, triglycerids and increased the seric level of HDL-cholesterol. These effects led to LDL cholesterol and the atherogenic index reduction. The improvement of the lipid profile was associated with the reduction of visceral fat. The plant extracts also significantly (P ˂ 0.01) reduced the amount of liver TG, the activity of seric transaminases, lipid peroxydation markers (plasma, liver, aorta) and increased tissue protein levels, SOD and catalase activity. The hydroethanolic extract was in a dose-dependant manner more effective than aqueous extract and metformine. These results showed that C. jagus extracts possess insulin sensitizing and antidyslipidemia activities, act against non-alcoholic hepatic steatosis and improve oxidative status on MACAPOS 1 diabetic rats. The results thus support the use of C. jagus in African folk medicine, mostly in obesity, diabetes treatment and likely its complications.

Keywords: Crinum jagus, diabetic rat MACAPOS 1, lipids parameters, insulin sensitivity, hepatic steatosis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia