EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ALTERNANTHERA SESSILIS (L.) R.BR. EX DC AND ALTERNANTHERA PHILOXEROIDES (MART.) GRISEB

Dr. R. Sivakumar* and D. Sunmathi

ABSTRACT

Objective: The aim of the present study was to evaluate the phytochemical screening and antimicrobial activity of ethanolic leaf extracts of Alternanthera sessilis and Alternanthera philoxeroides. Method: Ethanol extracts of both the plants were evaluated against four gram positive bacterial species (Staphylococcus aureus MTCC 96, Staphylococcus heamolyticus MTCC 3383, Enterococcus faecaalis MTCC 439, Bacillus subtilis MTCC 10619) and four gram negative bacterial species (Klebsiella pneumoniae MTCC 3384 , Escherichia coli MTCC 443 , Proteus vulgaris MTCC 1771 and Proteus mirabilis MTCC 442) and fungi (Candida albicans MTCC 227) using well diffusion method. Result: Phytochemical studies revealed the presence of alkaloids, flavonoids, aminoacids, carbohydrates, phenols, steroids, terpenoids, saponins and glycosides in both the plant extracts. The results of the study revealed that all the bacterial strains and fungi (Candida albicans) were more sensitive to A.sessilis than A.philoxeroides. The extracts were compared with standards like Gentamycin and Nystatin for antibacterial and antifungal activity respectively. The extracts showed remarkable inhibition of zone of bacterial and fungal growth and results were comparable with that of standard drugs against the organism tested. Conclusion: In conclusion, leaf extract of A.sessilis and A.philoxeroides showed significant antimicrobial activity. It may be due to the phytochemicals present in them.

Keywords: Alternanthera sessilis, Alternanthera philoxeroides leaves, antibacterial, antifungal, Gentamycin and Nystatin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia