EVALUATION OF CARRAGEENAN INDUCED ANTI-INFLAMMATORY ACTIVITY OF KADUKKAI PODI TERMINELIA CHEBULA (Retz). IN ALBINO WISTAR RATS

Dr. M. Rosalyn Shobanaa*, Dr. R. Ajanthan and Dr. A. Manoharan

ABSTRACT

The Inflammation is a complex biological response of vascular tissues against aggressive agents such as pathogens, irritants, or damaged cells. Acute inflammation is the initial response and is characterized by the increased movement of plasma and innate immune system cells, such as neutrophils and macrophages, from the blood into the injured tissues. The anti-inflammatory activity of the kadukkai Podi was evaluated by carrageenan-induced rat paw oedema method. Male albino rats (180 ± 5 g). The results obtained indicate that the kadukkai Podi had significant anti-inflammatory activity in rats. It reduced the edema induced by carrageenan by 55.30% and 57.53% on oral administration of 100 and 200 mg/kg, as compared to the untreated control group. The inhibitor of leukocyte migration and the formation of pleural exudates when given orally. Thus it can be concluded that the siddha single drug kadukkai Podi possess significant anti-inflammatory activity in rats.

Keywords: Siddha Single Drug Kadukkai Podi, Anti-inflammatory, carrageenan-induced rat paw oedema method.