EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREPARATION AND EVALUATION OF FERROUS GLYCINE SULPHATE TIMED RELEASE DOSAGE FORM

B. Shyamala Devi, R. Kumaravelrajan* and V. Suba

ABSTRACT

Objective: Extrusion spheronization is a widely used multi-stage technique that can produce spherical particles of almost uniform size. In order to evaluate the effect of the substitution of microcrystalline cellulose with different amounts of ethyl cellulose on the mechanical properties and release properties of ferrous sulphate glycine matrix particles prepared by extrusion spheronization, this study was conducted. Method: Therefore, the ethyl cellulose used in the formulation test ranges from 0-40%, and the maximum MCC is 85%. The yield of pellets was in the range of 70-90.5% and was influenced by EC percentage. Results: Inclusion of EC changed the mechanical properties of pellet, and affected drug release rate and therefore was able to make sustained release matrix pellets up to 4 hr it was observed that, the ferrous glycine sulphate pellets, as an iron compound was found to produce an improved effect comparing to the standard. Conclusion: Results revealed that EC could not be used as a sole polymer in production of Ferrous glycine sulphate matrix pellets by extrusion-spheronization and at least 20% level of MCC was necessary in the process. Data between groups were compared statistically by t-test and values of P<0.0001 were considered statistically significant.

Keywords: Ferrous glycine sulphate, Pellets, Timed-release, Extrusion-Spheroinzation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )