A SHORT REVIEW ON IN- SITU GEL FORMULATION FOR OCULAR DRUG DELIVERY: ITS PREPARATION AND EVALUATION
Anshul Sharma*, Mohit Panwar, Suryakant Verma, Sachin Tyagi
Conventional ocular drug delivery systems like eye drops, ointments, suspensions has varied disadvantages of lachrymation, blurred vision and most vital speedy precorneal elimination, therefore so as to beat these drawbacks varied novel approaches were developed. in place ocular gel is one in every of the recent advancement in ocular drug delivery system. in place ocular gel system comprise delivery vehicle composed of polymers (natural, semi artificial or synthetic) that incorporates a special property of sol-gel conversion once influenced by some biological input like pH scale, temperature and ions. The developed formulation was therapeutically efficacious, stable, non bother and provided sustained unleash of the drug. This review tries to debate the newer Developments and techniques for this drug delivery together with physiological factors, physiochemical factors and formulation factors to be thought-about within the Development of unchanged drug delivery system.
Keywords: In – situ ocular gel, temperature dependent system, pH sensitive system, ion-activated system, polymers, cul- de- sac, etc.
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