BIOLOGICAL SCREENING AND SYNTHESIS OFSUBSTITUTED NOVEL 6, 7-DIMETHOXY-4-(3, 4, 5-TRIMETHOXYPHENYL)-3, 4-DIHYDRONAPHTHALEN-1(2H)-ONE

Ranjini P., Chaitramallu M., Shilpa and Devaraju Kesagodu*

ABSTRACT

The field of biomedical analogs of podophyllotoxin is still in its infancy, but the explosion of interest in these molecules as inherently active therapeutic agents is increasing. There is growing interest in the design and synthesis of novel biocompatible analogs. The series of novel substituted podophyllotoxin derivatives were synthesized under mild conditions with satisfactory yield. The recorded results of lipid peroxidation with treated samples were increasing with increasing concentration. Auto dock server analysis of the these analogs structure showed that the compounds were shown to interact with the proteins involved in Bcl-xL mediated pathway with inhibition constant of 0.000149 and 0.000584 for 5G and 5C respectively.

Keywords: Podophyllotoxin, docking study, Tryphan blue assay, Auto dock, angiogenic effect.