EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AN OVERVIEW OF PHARMACOSOMES AS NOVEL VESICULAR DRUG DELIVERY SYSTEM

Supriyo Nej*, Dr. Falguni Patra and Dr. Beduin Mahanti

ABSTRACT

Novel drug delivery systems mainly focus on attaining the desired concentration of drug at the target site for the intended period of time using various carrier systems. Pharmacosomes are amphiphilic phospholipid complexes of drugs bearing active hydrogen that bind to phospholipid. The evaluation of pharmacosome is done on basis of different parameters such as size, surface morphology and in vitro release. Pharmacosomes are used as potential alternative for conventional vesicles like liposomes and nisomes because they produce a unique advantage over these conventional vesicle. They act by making an amphiphilic phospholipid complex with drug bearing active hydrogen atom covalently that bind to phospholipids. Pharmacosomes are also useful for maintaining low toxicity level of drug by minimizing the side effects. Pharmacosomes are used to achieve grater shelf life and better stability of drug. Bioavailability of poorly soluble drug increased by pharmacosomes and they also help to minimize the degradation of the drug. Using pharmacosomes as vesicular drug delivery system is economical compared to other technique. The drug releaseof pharmacosome is controlled by the process of enzymatic reaction and acid hydrolysis. Pharmacosomes are used for drug targeting in cancer and brain by using 3,5 – dioctanoyl – 5 – fluro – 2 – deoxyuridine. Pharmacosomes are capable of incorporating both hydrophilic and lipophilic drugs.

Keywords: Pharmacosomes, amphiphilic, Drug targeting, novel drug delivery system, phospholipids, bioavailability.


[Full Text Article]

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  • New Issue Published

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )