FORMULATION DEVELOPMENT AND EVALUTION OF MEDICATED CHEWING GUM OF AVANAFIL

Mr. Rikin Patel*, Miss. Twinkle J. Patel* and Dr. Rahil G. Bhura*

ABSTRACT

Medicated chewing gum- A growing trend in pharmaceutical world. Introduction: Medicated chewing gum is defined as a single solid dosage form containing active ingredient along with the excipients which is intended to be chewed for the release of the active ingredient and rest mass to be discarded out. Medicated chewing gums are usually used to treat diseases related to mouth, throat or for Erectile dysfunction. Avanafil being a Phosphodiesterase-5 (PDE-5) Inhibitor drug which is used for erectile dysfunction. Avanafil have faster onset of action as well as higher specificity for phosphodiesterase type 5 inhibitors with fewer side effects in comparision of other oral phosphodiesterase type 5 inhibitors drugs. Objectives: Avanafil being a BCS class II drug shows less of absorption and bioavailability. Medicated chewing gum overcomes such problems and which also increases the patient compliance. Materials and Methods, Evaluation and Conclusion: Avanafil along with Polyvinylacetate, Sucrose, Peppermint flavour, Glycerine, Calcium Carbonate, Aspartame, Mannitol, ß-cyclodextrin (ß-CD) was used to formulate the medicated chewing gum. Preliminary batches were prepared with a deep literature survey and best batch from it was selected for optimization of further batches. Evaluation was carried out of the formulated batches along with the stability studies and buccal permeation showing satisfactory results. Thus formulation of Avanafil into medicated chewing gum was done successfully.

Keywords: Medicated chewing gum, Avanafil, Erectile dysfunction, fast onset of action, increase in bioavailability, % drug content, % drug release.