( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Mr. Rikin Patel*, Miss. Twinkle J. Patel* and Dr. Rahil G. Bhura*


Medicated chewing gum- A growing trend in pharmaceutical world. Introduction: Medicated chewing gum is defined as a single solid dosage form containing active ingredient along with the excipients which is intended to be chewed for the release of the active ingredient and rest mass to be discarded out. Medicated chewing gums are usually used to treat diseases related to mouth, throat or for Erectile dysfunction. Avanafil being a Phosphodiesterase-5 (PDE-5) Inhibitor drug which is used for erectile dysfunction. Avanafil have faster onset of action as well as higher specificity for phosphodiesterase type 5 inhibitors with fewer side effects in comparision of other oral phosphodiesterase type 5 inhibitors drugs. Objectives: Avanafil being a BCS class II drug shows less of absorption and bioavailability. Medicated chewing gum overcomes such problems and which also increases the patient compliance. Materials and Methods, Evaluation and Conclusion: Avanafil along with Polyvinylacetate, Sucrose, Peppermint flavour, Glycerine, Calcium Carbonate, Aspartame, Mannitol, ß-cyclodextrin (ß-CD) was used to formulate the medicated chewing gum. Preliminary batches were prepared with a deep literature survey and best batch from it was selected for optimization of further batches. Evaluation was carried out of the formulated batches along with the stability studies and buccal permeation showing satisfactory results. Thus formulation of Avanafil into medicated chewing gum was done successfully.

Keywords: Medicated chewing gum, Avanafil, Erectile dysfunction, fast onset of action, increase in bioavailability, % drug content, % drug release.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 June 2021 Issue has been Published, Kindly check it on


    JUNE Issue has been successfully launched on 1 June 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )