FORMULATION AND DESIGN OF CURCUMIN GASTRO RETENTIVE FLOATING TABLETS.

Mamatha G.T., Shashanka K.N.*, Parthiban S. and Senthil Kumar G.P.

ABSTRACT

The purpose of the present study was to develop gastro retentive floating tablets of Curcumin using polymers such as HPMC K4M, Ethyl cellulose and xanthan gum. Formulations were prepared by direct compression method and evaluated for Hardness, Thickness, Weight variation, Friability, Drug content, Floating lag time, Total floating time, Swelling index, Invitro drug release. Among all the formulations FC7 formulation as got the higher percentage of drug release when compare to the other formulations. At the end of the result we can concluded that formulation FC7 containing the combination of three polymers HPMC K4M, Ethyl cellulose and Xanthan gum in the ratios of (3:1:1) got highest percentage of drug release that will enhances the bioavailability and absorption of drug.

Keywords: Curcumin, floating lag time, floating drug delivery system.