EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STUDY ON CAROTID INTIMAL THICKNESS IN RHEUMATOID ARTHRITIS PATIENTS AS MARKER OF ATHEROSCLEROSIS IN RURAL POPULATION OF KOLAR DISTRICT

Dr. Prabhakar K., *Dr. Sridhar Sreenivasan G., Dr. Reddy Prasad K., Dr. Vidyasagar R. and Dr. Prajeet R

ABSTRACT

Objectives: 1.) To find the association of carotid intimal thickness in rheumatoid arthritis patients. 2.) To study carotid intimal thickness in healthy controls. 3.) To compare the carotid intimal thickness in rheumatoid arthritis patients with age and sex matched healthy controls. Materials and Methods: A total of 138 people were selected for the study. Subjects for the study were selected from R. L. Jalappa Hospital and Sri Narasimharaja (SNR) Government Hospital, Kolar, who were diagnosed with rheumatoid arthritis according to the RA ACR/EULAR 2010 criteria. The control group consisted of healthy, non-diabetic, non-hypertensive and non-smoking subjects who were selected from the patient bystanders attending the hospital. Carotid intima-media thickness was measured in both sets of cases and was compared with age and sex matched controls. Results: A significant difference was found between cases and controls. Mean Right CIMT (mm) in cases was 0.58 ± 0.15 and in controls was 0.47 ± 0.04. Mean Left CIMT (mm) in cases was 0.60 ± 0.15 and in controls was 0.46 ± 0.04, which shows a positive correlation between rheumatoid arthritis and an increase in carotid intima-media thickness (CIMT). ESR, CRP and RA factor also showed a positive correlation with CIMT. Conclusion: The study established that subclinical atherosclerosis, identified through CIMT, is a surrogate marker in patients with rheumatoid arthritis. A positive correlation was also established between duration of disease, ESR, CRP, RA factor and increasing CIMT.

Keywords: rheumatoid arthritis, atherosclerosis, carotid intima-media thickness.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )