EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF RAPID ANTIGEN TEST PERFORMANCE WITH CLINICAL REFERENCE STANDARD rRT-PCR TEST IN SYMPTOMATIC COVID-19 PATIENTS AT A TERTIARY CARE HOSPITAL, HYDERABAD.

Dr. Shaik Sumayyah Banu, Dr. L. Prashanthi*and Dr. G. Jyothilakshmi

ABSTRACT

Background: Covid-19 pandemic emerged as a major public health emergency affecting healthcare services all over the world. Many manufacturers have developed different diagnostic kits for early diagnosis and treatment. But there is paucity of performance data on different diagnostic tests hence there is need for evaluation of rapid antigen test (RAT) performance with the clinical reference standard real-time reverse transcription-polymerase chain reaction (rRT-PCR) test. Methods: The Standard Q Covid-19 antigen test kit (SD Biosensor, Inc., Gurugram) performance was compared with the real-time RT-PCR test kit (ICMR-NIV 2019-nCoV Assay) for detection of SARS-CoV-2. The nasopharyngeal specimens from 1255 symptomatic suspected Covid-19 patients attending Osmania General Hospital, Hyderabad during Sept 2020--Feb 2021 were subjected for both the diagnostic tests. Results: Out of 1255 cases, 285 (22.7%) were positive, and 970 (77.2%) were negative for SARS-CoV-2. Out of 285 positive cases, 68 (23.8%) were rapid antigen test positive. The overall sensitivity of RAT was 23.8% and specificity was 100%. The sensitivity of RAT decreased as the duration of symptoms on testing date increased and specificity remained constant. Comparatively good sensitivity (67.9%) was seen when subjected to RAT in less than 3 days of duration of illness. Conclusions: To conclude, rapid antigen test sensitivity decreased with the increase in duration of illness and true positives reflected mean cycle threshold value of <20 whereas false negatives showed mean cycle threshold >25 on rRT-PCR test indicating that the variation in viral load reflects the rapid antigen test sensitivity.

Keywords: COVID-19, SARS-CoV-2, Rapid antigen test, rRT-PCR, cycle threshold value.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )