EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVELUATION OF SUSTAINED RELEASE TABLETS OF REPAGLINIDE

*N. Rajitha, R. Sunitha, V. Lokesh Babu and A. Srinivasa Rao

ABSTRACT

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin dependent diabetes mellitus (NIDDM). Repaglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. Solid dispersions is the techniques and the most attractive processes to improve solubility of poorly soluble drugs. Here the solubility of Repaglinide is enhanced by solid dispersions with PEG 6000 and urea as carriers. Among the various solid dispersions prepared, the formulation FSDPN3 i.e., the solid dispersion of Repaglinide with PEG6000 prepared by Fusion method shows faster dissolution rate it was decided to use formulations FSDPN3 to formulate sustained release tablets using different polymers like HPMC, EC ,Guar gum and Xanthum gum by direct compression technique. Among the various sustained release tablets of Repaglinide solid dispersion prepared, the formulation F2 shows complete release of drug in 12 hrs, which is considered as best formulation for sustained release tablets of Repaglinide.

Keywords: Antihyperglycemic, postprandial, xanthum gum, direct compression technique.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia