EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL SCREENING AND INVESTIGATION OF INVITRO ANTHELMINTIC ACTIVITY OF AERIAL PARTS OF RUTA GRAVEOLENS L. (RUTACEAE)

*Mariyumma Kutty V T, Harishma Haridas, Hina Femin and Harsha Rajan NM

ABSTRACT

Background: Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally. The control of these nematodes has relied largely on the use of a limited number of anthelmintic. However, resistance to many of these anthelmintic is now widespread and therefore, there is a need to find new drugs to ensure sustained and effective treatment and control into the future. Methods: The aerial parts of plant extract of Ruta graveolens was prepared by Soxhlet extraction method and phytochemical screening was performed according to the preliminary chemical tests. Then the methanol, ethyl acetate and aqueous extracts were evaluated for its anthelmintic activity against adult Indian earth worms Eudrillus eugeniae (family: Eudrilidiae). Three concentrations (25, 50 and 75mg/ml) of each extract were studied, which involved for the determination of time of paralysis and time of death of the test worms. Albendazole in same concentration as that of extract was used as standard reference and normal saline as control. Results: It was found that methanol (49±0.22) and ethyl acetate (65 ±0.24) extracts exhibited significant anthelmintic activity while aqueous extract (89±0.22) show least activity. Conclusions: These results suggest that extracts from Ruta graveolens have promising anthelmintic activity and that more broadly, plant extracts are a potential rich source of anthelmintic to combat helminthic diseases. Further it would be interesting to isolate the responsible phytoconstituents, which are responsible for the anthelmintic activity and the mechanism of action, which is being attempted in the laboratory.

Keywords: Anthelmintic activity, Ruta graveolens, albendazole, Eudrillus eugeniae.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )