EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MICROALBUMINURIA AS A PREDICTOR OF ON EARLY NEUROLOGICAL DETERIORATION IN ACUTE ISCHEMIC STROKE

Dr. Prabhakar K., Dr. Pujitha S. N.* and Dr. Phaneesh Bharadwaj B. S.

ABSTRACT

Background: Stroke is a major cause of long-term disability among patients. Early Neurological Deterioration (END) has serious consequences on the short term (morbidity and death) and long term (recovery from stroke) outcomes in patients with acute ischemic stroke (AIS). Studies have shown a higher prevalence of microalbuminuria in those patients with AIS (1). This study was done to evaluate microalbuminuria as a predictor of END in acute ischemic stroke. Methods: An observational prospective study was conducted among AIS patients who presented to the department of General medicine, R L Jalappa Hospital (RLJH) from march 2018 to august 2019. 73 patients with first episode of acute ischemic stroke presenting within first 24 hours after onset of symptoms were enrolled in the study. The neurological status and the severity of stroke were assessed by applying the NIHSS (National Institute of Health Stroke Scale) score on day 1 and day 3 on all patients. END was diagnosed if there was an increase in the NIHSS score by 3 or more from day 1 to day 3 of admission. Presence of microalbuminuria in patients were assessed by calculating UACR at presentation. Microalbuminuria was then correlated with END in these patients. Results: Microalbuminuria was present in 80% of patients whereas in group without END, 18.86% had microalbuminuria.(p < 0.001). The presence of microalbuminuria was significantly more among patients who developed END. It was also found that patients with severe stroke (75%) were more in the group with END compared to those without (37.73%) with p value of <0.001, which was statistically significant. Conclusion: Results of our study suggests that presence of microalbuminuria can predict development of early neurologic deterioration in acute ischemic stroke patients and hence to be treated aggressively.

Keywords: Acute ischemic stroke, Early Neurologic Deterioration, Microalbuminuira.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )