EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IN-SILICO DESIGN AND PHARMACOKINETIC PREDICTION STUDIES OF NOVEL BENZOTHIAZOLE CLUBBED OXADIAZOLE DERIVATIVES FOR ANTI-DIABETIC ACTIVITY

Jinsha V.V., Babu G. and Shiny George*

ABSTRACT

Diabetes is one of the pre-dominant metabolic disorders all over the world. It is an increasingly important condition globally and robust estimates of its prevalence are required for allocating resources. In this regard, we have designed and evaluated a small library of twenty derivatives of benzothiazole clubbed oxadiazole in search of potent anti-diabetic agents through in-silico studies using Glide 5.5 extra precision (XP) maestro Schrodinger software. Compounds 5A, 5B, 5J and 5K shows excellent activities on PPAR-γ and compounds 5A, 5B, 5D, 5H, 5J, 5K and 5L showed good activities on α-glucosidase and α-amylase than standard drug acarbose. Comparatively designed compounds shows least activity on DPP4 receptor. Molecular docking studies were done to assess the binding mode and interactions of synthesized hits at binding site of receptors. Results of in-silico studies showed that most of the compound have excellent drug likeness properties, pharmacokinetic profile and are preferable as an orally available drug. Here in we conclude benzothiazole incorporating oxadiazole could be considered as promising scaffolds towards the development of novel antidiabetic agents.

Keywords: Benzothiazole, oxadiazole, anti-diabetic potential, in-silico studies, Schrodinger.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )