FORMULATION AND EVALUATION OF FAMOTIDINE FLOATING MATRIX TABLETS
Km. Shivani Sharma*, Mohammad Mujahid and Dr. Shamim Ahmad
The aim of this research studies was to formulate a drug delivery system for Famotidine. This study examined the usage of a 3-factor, 3-level BoxBehnken project and efficacy of a floating pill for the famotidine pill with five-point center facts. The value of HPMC K4 (Hydroxy Propyl Methyl cellulose), the quantity of HPMCK15 and the quantity of HPMCK100 were designated as self-governing variables and the floating time (TFT), half-life,% 10 hours drug release, and distribution coefficients (n) selected as the dependent variant. Prepared tablets for famotidine were tested for a complete elimination study and were obtained following zero order kinetic release. Responses were analyzed using ANOVA and separate reply limits were assessed using an F test and a polynomial equation designed for each response using the MLRA. The amount of HPMC K4 and the amount of HPMCK15 were found to have a significant effect on all selected response fractions and the amount of HPMCK100 had a significant effect on TFT. A moderate amount of HPMC K4, HPMCK100, and HPMCK15 are essential for achieving a good float time and a small amount of floating cell. It’s clear from the scatter profiles that the batches F3, F7, and F8 showed the first stage of the explosion in the first hour of completion. The explosion phase was followed by a limited drug release all the time. The pills produced showed a good time floating and controlled drug release for a period of 12.
Keywords: Famotidine, Gastro retentive floating tablet, Box-Behnken Design, Hydroxy Propyl Methyl Cellulose.
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