EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE EVALUATION OF POTENTIAL HYPOGLYCEMIC EFFECT OF CAPE GOOSEBERRY (PHYSALIS PERUVIANA, FAMILY: SOLANACEAE) LEAVES

Almeda Jamie Joy B., Esclamado John Cyrell B., Marin Anthony R.*, Robles Reynalyn R., Simbulan Camille Irish M., and Umali Gerome L.

ABSTRACT

Diabetes Mellitus is a medical condition that affects our body’ use of its blood sugar and it is important because it fuels a lot of things our brain, our muscles and tissues, and if our body’s blood sugar malfunctions, it can make a person experience fatigue, making the person weak. Thus, this study aims to check the potential hypoglycemic effect of Cape Gooseberry. Cape Gooseberry is an indigenous plant found in the Andes, and is suspected to have a hypoglycemic effect on humans. To test its effectivity a total of 16 rats were utilized and each treatment has 4 rats during the experimentation. The study deployed four groups/treatments namely; No Treatment as Control Group, Distilled Water as Negative Control, Glibenclamide as Positive Control and Cape gooseberry. Rats were force fed with glucose solution to increase glucose level before treatments. Results show that the sugar level in the No Treatment as Control Group is significantly higher than the rest of the group/treatment. The glucose level during post inducement is not statistically different with the glucose level in the post-treatment for no treatment as Control Group. The absence of treatment does not lower glucose level. Glibenclamide is a drug known for treating diabetes mellitus type 2 and is a poorly water soluble drug, it proves its consistency in lowering glucose level and was used to compare its effects to Cape Gooseberry, it showed that Cape Gooseberry has a potential hypoglycemic effect. Cape Gooseberry can be a potential substitute to Glibenclamide in lowering glucose level.

Keywords: Glibenclamide; Rat; Physalis Peruviana; Potential Hypoglycemic effect.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )