FORMULATION AND EVALUATION OF HYDROGEL BASED ORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM FOR ACYCLOVIR

Shweta P. Jadhav*, Jayadev N. Hiremath, Nagond Mukund M., Anita R. Desai, and Chandrashekar V. M.

ABSTRACT

The goal of this study was to develop hydrogel based oral controlled release acyclovir matrix tablet capable of delivering drug at prolonged rate, suitable for once a day administration. The highly swollen hydrogel (CHGL) was prepared by cross linking the chitosan with glutaraldehyde (crosslinking agent). It was analysed by FITR spectra. Among 10 formulations, 6 formulations containing Hydrogel and HPMC K 100 in different ratio were prepared by wet granulation method using suitable polymers. The prepared matrix tablets were evaluated for pre compression and post compression parameters. The compatibility study was done by FTIR method. In- vitro release study was performed for 12 hours by using USP type-2 dissolution apparatus. SEM revealed that surface of tablet appeared porous with polymeric erosion after the dissolution testing. The drug release was found to be best fitted by Higuchi square root model. The formulation F8 has shown best results for all parameters as per pharmacopeia standard.

Keywords: Oral controlled drug delivery system, Cross linked chitosan (CHGL), hydroxy propyl methyl cellulose (HPMC).