A REVIEW OF HPV-RELATED AND NON HPV- RELATED HEAD AND NECK CANCER

Upma Tomar*, Sanjeev Tomar and Shivani Bhandari

ABSTRACT

Oral Malignancies are one of the commonest causes for mortality and morbidity with squamous cell carcinoma, as it is the sixth most frequent malignant tumour worldwide. In addition to tobacco and alcohol, human papilloma virus (HPV) is associated with a proportion of head and neck cancers. As in cervical cancers, HPV types 16 and 18 are the cause of malignant transformation. HPV- positive cancers of head and neck have unique characteristics such as occurrence in a younger age group, distinct clinical and molecular features, and better prognosis as compared to HPV- negative carcinomas. They also possess the potential for prevention by using vaccination. The current review depicts in detail the notable highlights of HPV related oral squamous cell carcinoma (OSCC), its disparities from HPV- negative OSCC, indicative highlights, and late techniques in avoidance and the board. In this audit, we will sum up the sub-atomic reason for this distinctive result, novel treatment openings and conceivable biomarkers for HPV positive HNSCC.

Keywords: HPV; HNSCC (Head and Neck Cancer); Radiation Therapy; Molecular Pathogenesis.