A REVIEW ON FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF ALLOPURINOL

Sandhya Gorakh Bansode*, Sagar Babasaheb Khedkar and Disha Vikas Kamble

ABSTRACT

The purpose of the review is to formulate and evaluate Allopurinol sustained release matrix tablet using different polymer as a release rate retarding agent which is also Xanthine Oxidase Inhibitors in nature by means of granulation method. The influence of the release rate by different diluents was studied. Formulation containing HPMC K 100 M and Methyl cellulose showed the sustained drug release pattern upto 12 hrs which matched the drug release pattern of innovator. Tablets thus formulated were evaluated for various physical tests like weight variation, hardness, friability and results complied with in the limits. Thus Xanthine Oxidase Inhibitors owing to the presence of its water soluble gummy constituents retards the release of the drug and also possess the antigout activity, Thereby sustained release matrix tablets thus formulated using polymer and Allopurinol exhibits.

Keywords: Allopurinol, Sustained Matrix drug, additive, Xanthine Oxidase Inhibitors.