BOTOX STORAGE AND TECHNIQUE

Dr. Munir Alam*

ABSTRACT

BOTOX® and BOTOX® Cosmetic (botulinum toxin serotype A) purified neurotoxin complex is distributed in vials of 100 U of sterile, vacuum dried crystalline powder without preservative. The 100 U vials of BOTOX® are shipped frozen in insulated, styrofoam containers. When it reaches its destination it can be stored in its dry, powdered form in the refrigerator at a constant temperature of 2–8°C1. Once reconstituted, the solution of BOTOX® can be stored again in the refrigerator at a constant temperature of 2–8°C. DO NOT REFREEZE RECONSTITUTED BOTOX®. Although the package insert for BOTOX® recommends the reconstituted product be used within four hours, studies have shown that after reconstitution, the potency of BOTOX® should remain consistent and unchanged for up to 6 weeks, and can be used without any noticeable change in clinical efficacy.[2,3]

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