DIAGNOSTIC VALUE OF INTERLUKEIN-18 IN RENAL FAILURE DISEASE

Heba Saber Abd El Fatah, Hamed Mohamed Abd El Barry, Shuzan Ali Mohamed, Eman Raafat Amer and Ibrahim El Tantawy El Sayed*

ABSTRACT

Background: End-stage renal disease (ESRD) is the last stage of chronic kidney disease which is related with significantly increased morbidity and mortality. Interleukin-18 (IL-18), a strong proinflammatory cytokine with multi properties. The aim was to evaluate the role of pro-inflammatory cytokine Interleukin-18 in end stage renal disease. Methods: This study was conducted on 150 subjects all collected from Benha teaching Hospital and were divided into three groups Group (1): control group composed of 50 healthy volunteer individuals. Group (2): 50 patients with renal failure. Group (3): 50 patients with renal failure and inflammation. Serum IL-18 was measured for all subjects. Results: Mean of IL-18 in controls, patients with renal failure, patients with renal failure and inflammation were 98.50±60.01, 548.78±140.73 and 1114.16±243.03 respectively. Mean value of urea and creatinine level was statistically significant higher among patients with renal failure and inflammation than controls. The mean value of urea and creatinine level was statistically significant higher among patients with renal failure and inflammation than patients with renal failure. The mean value of urea and creatinine level was statistically significant higher among patients with renal failure than controls. There were statistically significant positive correlations between IL-18 and (Glucose and CRP), while negative correlations between IL-18 and albumin. Conclusion: IL-18 levels were elevated in renal failure patients than controls. Serum IL-18 is significantly increase in renal failure patients and is correlated with inflammation. So, IL-18 can be used as non-invasive pro inflammatory marker for detection of the chronicity and severity in renal failure patients.

Keywords: Il-18- renal failure-end stage renal disease.