EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ISOLATION OF STEROLS FROM OCIMUM SANCTUM L. LEAVES AND IT’S INHIBITORY ACTION ON GLUCOAMYLASE IN VITRO

Gangadhar A. Meshram*, Ganesh S. Metangale, Shraddha Khamkar and Tanushri Kulkarni

ABSTRACT

Diabetes Mellitus is the major chronic disease caused by an improper balance of glucose homeostasis. The hydrolysis and intestinal absorption are carried out by a group of hydrolytic enzyme, which includes salivary α- amylase and intestinal α-glucosidases, respectively. Plant based remedies have always been an integral part of traditional medicine throughout the world. Ocimum Sanctum L. (Tulsi) extracts are used as Ayurvedic remedies for common cold, headache, stomach disorders, inflammation, heart diseases, various forms of poisoning and malaria The active fraction containing mixture of stigmasterol and β-sitosterol was isolated by silica gel column chromatography and structure was determined using spectroscopic analysis. The inhibitory effect of glucoamylase parameter was determined in vitro. The isolated mixture of compounds shows moderate inhibitory effect at 1μg/mL concentration with 33.33% inhibition. The enzyme inhibition could be part of the mechanism by which they are used in the treatment of the type-II diabetes. However, stigmasterol and β- sitosterol may play an important role in glucoamylase inhibition action. Research studies leading to extraction, isolation, identification and biological evaluation of plant constituents have now formed the major field of study.

Keywords: Ocimum Sanctum L., stigmasterol, ?- sitosterol, glucoamylase.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )