( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Ukwueze S. E. and Nkangwung M. J.


Recently, multisource psychotropic medications have become the mainstay of clinical management of psychotic and neurological disorders resulting in decreased treatment cost. The World Health Organization (WHO), however, had estimated that 30 % of the medicines in circulation in low- and middle-income countries, like Nigeria, are substandard and counterfeit, thus, posing serious public health challenge to patients. The objective of this study was to evaluate the degree of compliance of different brands of risperidone with pharmacopeia standards. Generic brands of risperidone were sourced from pharmacies in south-south states of Nigeria and analyzed for uniformity of weight, hardness, friability, disintegration, and dissolution profiles. The content of active ingredients and similarity factor (F2) of the dissolution profiles for the tablets were also determined. All the tests were done according to USP and BP specifications. Risperidone content was determined at a wavelength of 241 nm using UVspectrophotometer. The innovator brand (R1) was applied as the reference standard. All the brands, passed the content of active ingredients assessment (> 95%), weight uniformity test (< 7.5 mg coefficient of variation), friability test (< 1.0%), disintegration test (< 10 min) and dissolution test (> 85% at 30 min). Only R1 and R2 passed the hardness test (> 4 kg/f)), while the comparison of their dissolution profiles via F2 determination gave values greater than 50, suggesting good potential for interchangeability of the brands. The study therefore indicated that the brands of risperidone available in Nigerian market met most of the stringent quality and safety standards necessary to ensure efficacy and interchangeability, but, the slight variations in some of the assessment parameters must be taken into account when brands are switched to avoid inconsistency in treatment outcomes.

Keywords: Risperidone, Substandard, Counterfeit, Pharmacopoeia, bioavailability, Similarity factor.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database