EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE ROLE OF CFDNA CONCENTRATION IN VARIOUS CARDIAC DISEASES AND IT’S CORRELATION WITH COVENTIONAL BIOMARKERS

Md. Sakibur Rahman Tapu, Gong Kaizheng*, Yao Deshan, Yuan Mengxuan and Guo Jiao Jiao

ABSTRACT

Objective: To quantify the concentration of plasma cfdna in patients with cardiovascular diseases and healthy volunteers at different stages, analyze the correlationship between plasma cfdna and traditional biomarkers with clinicopathological features of cardiovascular patients. Additionally, evaluate its significance in early clinical diagnosis of cardiac disease state. In recent years cell free DNA’s are coming under spotlight while establishing it’s significance in the field of precision medicine. Over the past decades it has been affirmed that larger amount of cell free DNA’s can be detected in the circulation with pathological condition which plays a significant role suggesting a noteworthy clinical part in cancer, Diabetes mellitus, Rheumatoid Arthritis, prenatal screening, inflammation, stroke, myocardial infarction and variety of cardiac diseases. Method: We purified cfDNA directly from peripheral blood using magnetic beads by modifying binding and lysis conditions followed by a spectrometric Dna concentration test. Result : The serum from cardiac patients showed significant cfDNA elevation (p<0.01). The interquartile value of cfDNA (median 136.79 μg/ml, range 10.54–263.04 μg/ml), (median 36.62 μg/ml, range 17.58-57.67μg/ml), (median 8.18μg/ml range 1.83-14.53μg/ml), (median 12.65 μg/ml range 4.67-20.63μg/ml) account respectively for Myocardial infarction, Cardiac angina, Atrial fibrillation, and cardiac failure vs. (median 5.46 μg/ml, range 1.38–9.54 μg/ml) indicating healthy controls patients were shown. In our study we didn’t find any significant correlation of cfDNA concentration with CRP and CK-MB respectively even though noteworthy elevation of cfDNA was observed in selected cardiac patients. Conclusion: These results enlighten us to brief that plasma cfDNA in cardiac patients may originate from apoptosis and suggest a impactful diagnostic validity.

Keywords: cfDNA, MI, biomarkers, CVD.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 June 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: JUNE ISSUE PUBLISHED

    JUNE Issue has been successfully launched on 1 June 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )