RISK FACTORS FOR THE DEVELOPMENT OF CKD IN PATIENTS WITH CORONARY ARTERY DISEASE

Sh. K. Muminov*

ABSTRACT

Purpose of the study: to determine the risk factors for the development of CKD in patients with coronary artery disease (CAD) after myocardial revaslarization. Material and methods. The study included 160 patients with coronary artery disease who underwent coronary angiography. The study included patients with eGFR over 60 ml / min. On the second day after the endovascular procedure, the patients underwent determination of the blood creatinine concentration to identify patients who developed contrast-induced nephropathy (CIN). In dynamics, at the end of the second year of follow-up all patients underwent repeated examination. Research results. CIN in the early period after endovascular intervention was observed in 37 patients. All patients with CAD included in the study were distributed depending on the eGFR achieved by the end of the 2nd year after revascularization. In 20% (32 out of 160) patients, an eGFR of less than 30 ml / min was achieved. Comparative analysis of the parameters revealed that patients with the worst prognosis in terms of the development of CKD were significantly older (p <0.01), they initially had more impaired renal filtration function (p <0.001). Conclusion. The most significant prognostic marker for the development of CKD IV-V in patients with coronary artery disease within 2 years after revascularization is the development of contrast-induced nephropathy in the early period after endovascular intervention (increases the risk of CKD IV-V by 7.31), the concentration of BNP in the peripheral blood serum is more than 587 pg / ml (increases the risk of CKD IV -V 10.16 times), LVEF less than 52% (increases the risk 9.72 times) and the sphericity index more than 0.62 units (increases the risk 8.77 times).

Keywords: chronic kidney disease, ischemic heart disease, contrast-induced nephropathy, echocardiography.