EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

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Abstract

INHIBITORY OF ?-AMYLASE AND ?-GLUCOSIDASE BY RAW, BOILED, AND ROASTED POTATOES

Man Kyu Huh* and In Sook Kye

ABSTRACT

This study was to evaluate and compare the α-amylase and α-glucosidase inhibitory activity of extracts from common brownish potato during two cooking methods. The α-amylase inhibitory activity of the raw potatoes was high, but not when boiled or toasted. α-amylase inhibitory activity of water extract for raw potato was evaluated 15.5% at 0.25 mg/ml and 38.4% at 1.0 mg/ml. The values of the boiled potato evaluated 16.3% at 1.0 mg/ml and that of the roasted potato evaluated 19.9%. There was no significant difference in the inhibitory activity of the two enzymes between boiled and roasted potatoes (p > 0.05). The half maximal inhibitory concentration (IC50) for α-amylase of raw potato was 170.8 ug/ml, whereas boiled potato was low, 209.7 ug/ml. α-glucosidase inhibition of water extract for raw potato evaluated at 0.25 mg/ml was 26.9% and that of 1.0 mg/ml was 51.5%. The values of α-glucosidase inhibition for boiled and roasted potatos evaluated at 1.0 mg/ml were 21.0% and 20.5%, respectively. The raw potatoes generally had slightly higher α-amylase and α-glucosidase inhibitory activity than boiled and roasted potatoes. Boiling and roasting treatments for potatoes showed reducing effects on the α-amylase and α-glucosidase inhibitory activity. The mode of inhibition of the raw potapo extracts against both α-amylase and α-glucosidase was confirmed by Lineweaver–Burk plots. Crude water extract competitively inhibited α-amylase and α-glucosidase.

Keywords: ?-amylase, ?-glucosidase, inhibitory activity, Lineweaver–Burk plots, potato.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia