EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION, DEVELOPMENT AND EVALUATION APPROACH FOR MUCOADHESIVE TABLETS

Gadekar Madhuri Rajendra*, Dr. Vijaya Barge and Dr. Ashok Bhosale

ABSTRACT

The present study has shown that Drug prepared tablets gave promising results in terms of mucoadhesive resistance and in vitro permeation of the dosage form. The present research was planned for the formulation and development of Drug hole-adhesive tablets with 2 factors, namely Moringa gum and Xanthan gum in 3 different levels. For the formulation of hole-adhesive tablets, MG and XG are used in 3 different levels with direct compressible lactose as a diluent. Fixed amount of ethyl Cellulose used as a support layer. The formulation variables include the nature and quantity of polymers and diluents with different physico-chemical properties, mucoadhesive resistance, swelling index studies, in vitro permeability studies and stability. Prestressing parameters such as rest angle, bulk density, shunt density, compressibility index and host ratio within the prescribed limits. The prepared oral adhesive tablets were evaluated for post-compression parameters such as hardness, weight variation, thickness, friability, and swelling index, uniformity of the drug content, surface pH, and mucoadhesive resistance. All prepared oral tablets were found to follow an abnormal non-Fickian release. The formulation was stable with respect to the content of the drug, permeation in vitro during the stability study period.

Keywords: Drug, mucoadhesive tablet, mucoadhesive resistance, Moringa gum and Xanthan gum.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )