EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND DEVELOPMENT APPROACH FOR TABLETS BY SOLID DISPERSION METHOD

Mayur Bhaskar Aware*, R. S. Bachhav and Dr. S. B. Gondkar

ABSTRACT

Authentication of the drugs was done by analytical techniques using FTIR, UV, and DSC. Further drug excipients compatibility was done and found that drugs are very well compatible with the other selected specified excipients. The Solid Dispersion technique has been performed as promising valued and cost effective technique for enhancing Solubility and Dissolution rate, compressibility and micrometric properties. “Solid Dispersion is an extension of spherical crystallization technique, which enables simultaneous crystallization and agglomeration of two or more drugs or crystallization of a drug and its simultaneous agglomeration with another drug or excipient.” The selected drug was characterized and identified by melting point : Solubility, partion coefficient, IR, DSC, XRD and for analysis of drug uv spectroscopy is done . For Solid Dispersion polymers and solvent system are selected and used with different concentration. Solid Dispersion are obtained with help of polymer, good solvent and bad solvent etc. Initial batches of Solid Dispersion were obtained of different concentration of PVP K90, PVP K30 and PVP K25. Solubility data was obtained in triplicate of preliminary batches. Optimization is done on 8 batches and further evaluated for its Solubility and % Drug Release. Out of 8 optimized batches batch was further used for study depending on Solubility data. Solid Dispersion showed enhancement in physicochemical and micrometric properties. From the above optimized Solid Dispersion batch Fast dissolving tablets were formulated by using various concentration of Polymer and wetting agent by direct compression method and different batches were studied for Dissolution study and disintegration time. From above discussion it was concluded that Fast dissolving tablet were prepared by direct compression method exhibited disintegration time 5 min and improved Dissolution rate.

Keywords: Drug, Solid Dispersion, Fast dissolving tablet, crystallization, micrometric.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )