EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND INVITRO EVALUATION OF ETHOSOMAL GELS CONTAINING GLIBENCLAMIDE AS THE MODEL DRUG

Sd Riyaz Hussain Chistia*, Dr. Pawan Kumar and Dr. Parwez Alam.

ABSTRACT

The process Touitou et al (2000) defined was used with little change to prepare various ethosomal formulations with different levels of IPA (20% to 40%) and sonicity. It was simple and reproductible techniques. The prepared and discrete ethosomes have been developed. However, ethosomes are more uniform in size and small, necessary for skin penetration by the process of sonication. When the efficiency of the trap was compared, ethosomes containing 30 percent w/w IPA, which were generated by sonication, displayed the highest value with respect to all others; Therefore, with 30 percent w/w IPA as the best formula for all other aspects, ethosomally provided by sonicity was completed. In all formulations, GF6 demonstrated full release of the drugs in 1,440 min compared to other formulations. The in vitro release decreased with increased concentrations of polymer and copolymer. Centered on the research findings of the drug release process the drug discharge followed the non-fickian diffusion mechanism by formulations and followed the first order kinetics.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )