EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

TO EVALUATE THE ANTI-ARTHRITIC AND IMMUNOMODULATORY ACTIVITY OF HYDROALCOHOLIC AND METHANOLIC EXTRACT OF QUISQUALIS INDICA LINN IN RATS

Falguni Jaiswal*, Dr. A. K. Rai, Dr. Parany Wal, Ankita Wal and Shashi Pratap Singh

ABSTRACT

Rheumatoid arthritis (RA) is characterized by joint inflammation and swelling, rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) production, and bone and cartilage destruction. In the present study the hydroalcoholic and methanolic extract of Quisqualis indica was administered orally at the dosage levels of 100 mg/kg and 200 mg/kg. The anti-inflammatory activity was test using acute inflammatory models like Formaldehyde induced arthritis and chronic models like Freund’s complete adjuvant arthritis. Oral administration of the extract at the doses 100 and 200 mg/kg b.w. exhibited dose dependent and significant anti-inflammatory activity in acute (formaldehyde induced arthritis, p< 0.0001) and chronic (freund’s adjuvant induced arthritis, p<0.0001). The pharmacological screening included evaluation of anti-arthritic and immunomodulatory activity of hydroalcoholic and methanolic extract of Quisqualis indica at the dose of 100 mg/kg, 200mg/kg in rats with CFA-induced arthritis and formaldehyde induced arthritis. In injected (right) paw, low dose and high dose hydroalcoholic extract exhibited 36.29 %, 44.28 % inhibition and low dose, high dose methanolic extract exhibited 37.38 %, 46.09 % inhibition respectively against CFA induced paw edema on 21st day as compared to indomethacin (49.01 %). Administration of Quisqualis Indica was found to increase phagocytic activity by stimulation of macrophages, total WBC and differential leukocytes count. So anti inflammatory activity of Hydroalcoholic and methanolic extract of Quisqualis indica can be attributed to bradykinin and PG synthesis inhibition property of polyphenols. Hence, present investigation established some pharmacological evidences to support the folklore claim that Quisqualis indica L. is use as anti-inflammatory, anti-arthritic agent and immunomodulatory activity.

Keywords: Arthritis, Quisqualis indica, immunomodulation, indomethacin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia