ANTI-HYPERLIPIDEMIC ACTIVITIES OF METHANOLIC EXTRACT OF MUSK MELON

Rajasree R. S.*, Sibi P. Ittiyavirah and Revathy Krishnan M.

ABSTRACT

Some of the plants, which we consume as part of our diet, are rich in bioactive compounds, which can heal various ailment, or it may supplement the action of the drugs, which we administer. Cucumis melo Linn is a fruit used in a different part of the world. It possesses various medicinal properties. The present study mainly focuses on the anti hyperlipidemic activity of the methanolic extract of muskmelon in high fat diet induced hyperlipidemia in Wistar albino rats. The result reveals a significant reduction in total cholesterol and Low-Density Lipoprotein (LDL). At the same time, an increase in High-Density Lipoprotein (HDL) levels compared to control and positive control group was observed. Combination of standard drug with test also produced a significant effect. The dose of the standard was reduced to half, and it was combined with a low dose of MECM. The results concluded that methanolic fruit extract (400 mg/kg) have potent anti-hyperlipidemic activity in high fat diet-induced hyperlipidemia model, when compared with Simvastatin, treated group.

Keywords: Cucumis melo, Low Density Lipoprotein, High Density Lipoprotein, Cholesterol, Hypolipidemic.