EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

PREVALENCE OF ELEVATED SERUM TRANSAMINASE LEVELS IN SOUTH INDIAN TYPE 2 DIABETES INDIVIDUALS AND THEIR IMPORTANCE IN CLINICAL PRACTICE

*Dr. R. Anil Kumar and Dr. Baburajendra B. Naik

ABSTRACT

Objective: To find out the prevalence of elevations of serum transaminase levels in south Indian type 2 diabetes individuals and associated risk factors. Research design and methods: 403 type 2 diabetes subjects were randomly selected, 203 from Karnataka institute of endocrinology and research an urban diabetic centre and 200 from Bagalkot rural diabetic centre. BMI and waist circumference were measured. A fasting and post prandial blood sample was drawn for estimation of plasma glucose by hexokinase method. HBA1C was measured by the high-performance liquid chromatography method using the Bio-rad Variant 2 turbo analyzer. Diagnosis of diabetes was made by using ADA criteria of fasting plasma glucose ≥126 mg/dl and HBA1c ≥6.5%. Liver function tests and lipid profile were analyzed in cobot C 311 biochemistry analyzer by standard methods. Results: Age distribution-18 to 90 years. Male diabetes subjects were 64.8%. Duration of diabetes range from new to >10 years. BMI range from <18.5 to >30 kg/square meters. Waist circumference range from <80 cms to >100 cms. AST was more than 31 units/L in 26.1% (105) and ALT was more than 30 units/L in 22.8% (92) of the type 2 diabetes individuals studied. Elevated ALT was found to have a statistically significant association with increasing waist circumference, increased fasting and post prandial glucose, increased triglycerides, total and direct bilirubin levels. Elevated AST was found to have a statistically significant association with increased LDL, TG, total and direct bilirubin levels. Conclusions: AST was more than 31 units/L in 26.1% (105) and ALT was more than 22.8% (92) of the type 2 diabetes individuals studied. Elevated ALT was found to have a statistically significant association with increasing waist circumference, fasting and post prandial glucose, triglycerides, total and direct bilirubin levels. Marginal elevation of ALT levels can be used as a marker to suspect NAFLD in type 2 diabetes.

Keywords: AST, ALT, Triglyceride, liver function.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )