A REVIEW ON NASO-PULMONARY DRUG DELIVERY SYSTEM

Tushar Jadhav*, Prof Rahul Sarode and Prof DR. K. R. Biyani

ABSTRACT

Nasal drug delivery has received a great deal of attention as a convenient, reliable and promising method for the systemic administration of drugs. It is especially for those molecules which are ineffective orally and only effective if administered by injection. This is due to high vascularity, large surface area, the avoidance of hepatic first pass metabolism, gut wall metabolism and/or destruction in gastrointestinal tract. Since nasal mucosa offer several benefits for target delivery, a wide variety of therapeutic compounds may be administered intranasally for topical, systemic and central nervous system action. Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to deliver the drugs to the treat most crisis CNS diseases (i.e. Parkinson’s disease, Alzheimer’s disease) because it requires rapid and/or specific targeting of drugs to the brain. It is well suitable for the delivery of biotechnological products like proteins, peptides, hormones, DNA plasmids for DNA vaccines to give enhanced bioavailability. Pulmonary drug delivery has attracted tremendous scientific and biomedical interest in recent years and has progress considerably within the context of local treatment for lung diseases, by virtue of enhanced local targeting and reduced systemic side effects with the administration of minute drug dosages. The present review is an attempt to provide some information concerning naso-pulmonary drug delivery system such as advantages, disadvantages, mechanism of drug absorption, anatomy of nasal cavity and respiratory tract, factors affecting nasal drug absorption, dosage form, novel drug formulations and recent advancement of nasal delivery system.

Keywords: Naso-Pulmonary drug delivery; Nose; peptides and proteins; vaccines; mucociliary clearance; nasal pulmonary; respiratory tract; anatomy and physiology; recent advancement; bioavailability.