EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A REVIEW ON DOMINATING DIABETIC COMPLICATIONS AND THEIR MANAGEMENT

M. Dheepthi*, S. U. Mohamed Afreeth, S. Suba Dhanisha and C. Sowmya

ABSTRACT

Diabetes, the most common global burden affecting people of all age groups. It is a chronic metabolic disorder, results in elevated levels of blood glucose. This could be due to beta cell destruction/dysfunction. Diabetes results in variety of Complications, among them, the micro and macro vascular complications are more predominant. The incidence of diabetes complications varies with genetic factors, environment, gender and race. Diabetic retinopathy is associated with loss of pericytes and it is classified as non-proliferative and proliferative types. Diabetic neuropathy is the inflammation of neurons causing burning and tingling sensation especially in arms and feet. Diabetic nephropathy refers to the damage of nephrons due to hyperglycemic condition which progress to end stage renal failure where GFR is reduced to less than 15ml/min. Microalbuminurea is the hallmark of nephropathy. Nephropathy and hypertension are correlated in diabetic individual by altered Renin-angiotensin-aldosterone system mechanism. Oxidative stress pays the way for endothelial dysfunction which further worsens the condition by resulting in insulin resistance. The insulin resistance cause perivascular fibrosis which is characterized by ventricle hypertrophy leading to cardiomyopathy. Plaque deposit trigger the incidence of heart failure and one among the risk factor for development of stroke. Occurrence of stroke is predominant due to inflammation of cerebral blood vessels. Antioxidants play a vital role in prevention of severity of complications. There is no cure for diabetes hence, proper adherence, life style modifications and regular screening help in eliminating the risk of mortality due to complications.

Keywords: Complication, Diabetes, Endothelial dysfunction, Macrovascular, Microvascular, Oxidative stress.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 April 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: APRIL ISSUE PUBLISHED

    APRIL Issue has been successfully launched on 1 April 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )