SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL INVESTIGATION OF SOME ISATOIC ANHYDRIDE DERIVED AMIDES

*Unuigbe Osaherunmwen Isonah and Cyril Odianose Usifoh

ABSTRACT

Amide is a class of organic compounds with diverse biomedical utilities. The purpose of this work was to synthesize amide derivatives with possible antibacterial activities. The method involves the reaction of each of the amines (propargylamine, benzylamine and 1-naphthy methylamine) with isatoic anhydride in DMF resulting in opening of isatoic anhydride ring with evolution of carbon dioxide. The compounds were purified using column chromatography and were characterized with the combination of Fourier transform infra-red, nuclear magnetic resonance, mass spectroscopy and elemental analyses. These compounds were then screened for the antibacterial activity using agar wells plate incubated for 24 hours at 37 °C and zone of inhibition were measured and recorded. The antibacterial screening of the synthesised and characterized compounds showed no zone of inhibition suggesting that none of the synthesized compound had antibacterial property against the tested bacteria strains.

Keywords: Antibacterial; Propargylamine; Benzylamine; 1-naphthy methylamine; Isatoic anhydride.