DETERMINATION AND EVALUATION OF CRUDE EXTRACTS OF BATUAN (GARCINIA BINUCAO LINN. FAMILY: CLUSIACEAE) FRUITS AS ANTI-HYPERLIPIDEMIC ON HIGH CHOLESTEROL DIET – INDUCED SPRAGUE DAWLEY RATS

Bilbao, Plaudine Yvonne A., Koo, Ryson M., Lajo, Marie Alelli P., Manalo, Catalina Victoria M., Marin, Anthony R. and Pascual, Sweet Mitzi M.

ABSTRACT

Hyperlipidemia is a major risk factor for heart disease, and this is the leading cause of death. Many people are suffering from hyperlipidemia and this ailment is one of the most common diseases in the Philippines. Herbal medicine is widely used throughout the world, especially in the Philippines, because it is cheap and readily available. Because of this, the researchers studied the anti-hyperlipidemic effect of Batuan (Garcinia binucao Linn.) to find a new source that can help treating hyperlipidemia. This study aims to determine and evaluate the antihyperlipidemic effect of Batuan fruits in Sprague Dawley rats. Extraction of Batuan was conducted by Maceration method using 95% Ethanol as solvent. A sample of 5 rats per group was employed in the study. Distilled water served as negative group, atorvastatin served as positive group and 50 mg/kg ad 100 mg/kg of Batuan extract served as treatment group. The test results for the significant difference of between post- inducement and post-treatment within group showed that Distilled water is not significant for HDL, LDL, TG, VLDL, and TC. For Atorvastatin, it significantly decreases the count of LDL, TG, VLDL, and TC, and significantly increase the HDL count. For 50 mg/kg Batuan extract, it significantly decreases the LDL, TG, and, TC and significantly increase the HDL count. For 100 mg/kg Batuan extract, it significantly decreases the LDL, TG, and TC and significantly increase the HDL count during post treatment.

Keywords: Batuan as hyperlipidemia, Garcinia binucao and lipids, Antihyperlipidemia in Garciania binucao, Garcinia binucao in HDL & LDL.