INFLUENCE OF LONG-TERM APPLICATION OF ANTI-HYPERTENSIVE DRUGS AND CONDUCTING THE "SCHOOL OF HYPERTENSION" ON THE DEVELOPMENT OF RISK OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ARTERIAL HYPERTENSION

*D. Z.Yarmukhamedova, N.B.Nuritdinova, Z.M.Shoalimova, M.S.Makhmudova, S.M.Shukurdjanova, M.?.Zubaydullaeva

ABSTRACT

To assess the impact of long-term use of antihypertensive drugs and the "school of hypertension" on the development of the risk of cardiovascular complications and quality of life in patients with arterial hypertension, 610 patients with AH of 1–2 degrees were examined. The duration of hypertension was 6.8 ± 1.6 years. Of the 610 patients examined, 231 (37.9%) were patients with degree I hypertension (mean age of patients was 46.7 ± 7.0 years) and 379 (62.1%) - with degree 2 hypertension (mean age 49.1 +6.92 years). Patients with grade 1 hypertension began to take 10 mg of enalapril per day as monotherapy (Enap, KRKA, Slovenia). Patients with grade 2 hypertension were divided into 2 groups, taking into account risk stratification. Group 1 (medium risk) took 10 mg of enalapril per day, group 2 (medium and high risk) started taking enalapril 12.5 mg with hydrochlorothiazide - a fixed combination - Enap HL. Analysis of the results of the study showed that after 4 weeks of taking enalapril there was a decrease in blood pressure from 158.2 ± 6.5 / 96.1 ± 4.9 to 142.2 ± 7.1 / 88.1 ± 5.9 mm Hg. Art. (p <0.001), 22% of patients reached the target blood pressure. At the same time, in the group taking Enap HL, blood pressure decreased from 159.6 ± 6.4 / 97.5 ± 3.8 to 139.4 ± 8.7 / 87.4 ± 7.1 mm Hg. Art. (p <0.0001). Assessment of patients the occurrence of cardiovascular complications in patients with AH of 1 degree with a high risk of 16.9%, with a very high risk of 1.7%, and in patients with AH of 2 degrees, this condition was 33% and 12.4%, respectively.

Keywords: arterial hypertension, cardiovascular risk, fixed combination, school-hypertension.