TO DEVELOPED COMBINATION OF KETOCONAZOLE AND CURCUMIN TOPICAL DELIVERY LOTION FOR TREATMENT OF FUNGAL INFECTION AND WHITE PATCHES ON SKIN

Chinmay Dahariya*, Anju Mishra, Ghanshyam Rathore and Jhakeshwar Prasad

ABSTRACT

The present study has been undertaken to development of Ketoconazole and Curcumin Topical Delivery Lotion for Treatment of Fungal Infection. Superficial fungal infections of the hair, skin are common yet often difficult to treat. Dermatophytes are one of the most common causes of tinea (capitis, manuum, pedis, cruris, corporis, barbae) and onychomycosis. Candidal infections and pityriasis versicolor, caused by Malassezia furfur, lipophilic yeast, are also among the most widespread superficial cutaneous fungal infections. Topical antifungal agents are compounded into different types of vehicles, such as creams, lotions, gels, or sprays. When applied to the skin surface, they readily penetrate into the stratum corneum to either kill the fungi or inhibit their growth, achieving clinical and mycologic eradication. Ketoconazole belongs to the class of drugs called azole antifungals. It works by stopping the growth of the fungus. The main classes of topical antifungal treatment modalities include the polyenes, the azoles, and the allylamine/benzylamines. Other topical antifungal agents include ciclopirox, a hydroxypyridone, thiocarbonate, haloprogin, and selenium sulfide. The high synergistic activity of combinations is encouraging and the potential drug delivery system for the combination of ketoconazole and Curcumin.

Keywords: Fungal infection; Topical drug delivery systems; Ketoconazole; Curcumin.